High Impact Research

Nature and plastics inspire breakthrough in soft sustainable materials

Biodegradable structures could revolutionize energy, information technologies and advanced medicine

Repair, Regrow, Regenerate - Scientists and engineers unlock the body’s healing powers

Northwestern researchers, including Samuel StuppGuillermo Ameer and John Kessler, are on the cusp of some superhuman breakthroughs, pushing the body’s boundaries through advances in regenerative medicine and engineering, with the goal of bringing healing and hope to countless people.

Severe spinal cord injuries repaired with 'dancing molecules'

Northwestern University researchers have developed a new injectable therapy that harnesses “dancing molecules” to reverse paralysis and repair tissue after severe spinal cord injuries. In a new study, researchers administered a single injection to tissues surrounding the spinal cords of paralyzed mice. Just four weeks later, the animals regained the ability to walk.

Photosynthesis-inspired process makes commodity chemicals

Northwestern University chemists have taken inspiration from plants to revolutionize the way an important industrial chemical is made. In a first for the field, the Northwestern team used light and water to convert acetylene into ethylene, a widely used, highly valuable chemical that is a key ingredient in plastics.

Northwestern, MIT researchers develop novel materials for energy and sensing

A team of researchers from Northwestern University and the Massachusetts Institute of Technology (MIT) has demonstrated the ability to fine-tune the electronic properties of hybrid perovskite materials, which have drawn enormous interest as potential next-generation optoelectronic materials for devices such as solar cells and light sources.

Synthetic materials mimic living creatures

Northwestern University researchers from the Center for Bio-Inspired Energy Science (CBES) have developed a family of soft materials that imitates living creatures. When hit with light, the film-thin materials come alive — bending, rotating and even crawling on surfaces.

‘Dancing molecules’ heal cartilage damage

Regenerative effects of dynamic molecules might be universal across tissue types, new research suggests.

New biomaterial regrows damaged cartilage in joints

Northwestern University scientists have developed a new bioactive material that successfully regenerated high-quality cartilage in the knee joints of large animals.

Mature ‘lab grown’ neurons hold promise for neurodegenerative disease

Northwestern University-led researchers have created the first highly mature neurons from human induced pluripotent stem cells (iPSCs), a feat that opens new opportunities for medical research and potential transplantation therapies for neurodegenerative diseases and traumatic injuries.

Aquatic robot inspired by sea creatures walks, rolls, transports cargo

Northwestern researchers have developed a first-of-its-kind soft, aquatic robot that is powered by light and rotating magnetic fields. These life-like robotic materials could someday be used as “smart” microscopic systems for production of fuels and drugs, environmental cleanup or transformative medical procedures.

A new wave of regenerative medicine born in movies

Materials science pioneer Samuel Stupp believes the future of regenerative medicine may be here sooner than we think. Concepts born in movies — operating suites equipped with 3D printers, lab-grown human tissue and implanted neurons — are now finding origins in Northwestern laboratories.

Group Member News

Bonfigli describes undergraduate research in Stupp group

North by Northwestern interviewed Sophia Bonfligli, a rising fourth-year undergraduate majoring in Biology, about her experience in the Stupp laboratory and her Summer Undergraduate Research Grant (SURG) project.

Shae Murphy receives Obama-Chesky Voyager Scholarship

Pre-med student looks to better understand women’s healthcare in the U.S. and how to improve it

Alvarez wins Nanotechnology Award from Spanish publication

Zaida Alvarez won the Women in Science Nanotechnology Award from Muy Interesante, a monthly science magazine in Spain. The award recognized her first-author publication in Science, which described the development of an injectable therapy that reversed paralysis in mice following severe spinal cord injury.

Dordevic named finalist for European Young Chemists’ Award

Postdoctoral fellow Luka Dordevic was named one of six finalists for the European Young Chemists’ Award at the early career researcher level. The award is given every two years to recognize and reward young chemists with outstanding achievements. All finalists will present their research on Aug. 30 at the European Chemical Society’s Chemistry Congress, with the top two presenters receiving gold and silver medals, respectively.

PhD Candidates Julia R. Downing, Sieun Ruth Lee Honored for DEI Efforts

Downing and Lee were named winners at the 39th Annual John E. Hilliard Lecture and Symposium

Alvarez wins Rafael Hervada Award for spinal cord injury research

Zaida Alvarez has received the Rafael Hervada Award for Biomedical Research in recognition of her recent first-author paper in Science describing an injectable therapy that reversed paralysis in mice following severe spinal cord injuries. The Hervada Award honors innovation in scientific and medical research, and is considered one of the top prizes awarded in Spain for biomedical research.

Yuan wins Baxter Young Investigator Award

Graduate student Shelby Yuan was named a 2021 Baxter Young Investigator Award winner for her work on “TGF-β1 Mimetic Peptide Amphiphiles for Cartilage Regeneration.” This marks the third consecutive year that a Stupp laboratory member has won a Baxter Award, as Alexandra Kolberg-Edelbrock and Zaida Alvarez received the honor in 2020 and 2019, respectively.

Meet the Researchers: Hiroaki Sai

Hiroaki Sai is a research associate in the Stupp laboratory. He first joined the group as a postdoctoral research fellow in the fall of 2014 after earning a PhD in Materials Science and Engineering from Cornell University in 2013.

Group Member Fellowships and Honors 

  • Nozomu Takata – Poster Presentation Award, Gordon Research Conference on Central Nervous System Injury and Repair, July 2023
  • Madison Strong – Ryan Fellowship, June 2023
  • Luka Dordevic – European Young Chemists’ Award Finalist, August 2022
  • Broderick Johnson – NDSEG Fellowship, March 2022
  • Shelby Yuan – Baxter Young Investigator Award, September 2021
  • Doruk Cezan – Ryan Fellowship, September 2021
  • Zijun Gao – Chemistry of Life Processes University Fellowship, August 2021
  • Federico Lancia – Rubicon Fellowship, Netherlands Organisation for Scientific Research, June 2021
  • Yang Yu – German Research Foundation Fellowship, January 2021
  • Broderick Johnson – Ryan Fellowship, March 2020
  • Cara Smith – NSF Graduate Research Fellowship, September 2019

Alumni News

Meet the Researchers: Cara Smith

Cara Smith recently completed her PhD in Biomedical Engineering and has been a member of the Stupp laboratory since the fall of 2017. In this interview, Smith summarizes her primary research project, describes her experience of working in the Stupp group, and shares her career aspirations.

Chow wins SFB Mid-Career Award

Lesley Chow, an Associate Professor of Bioengineering and Materials Science and Engineering at Lehigh University, received the Mid-Career Award from the Society for Biomaterials (SFB). The award recognizes an individual SFB member who has demonstrated outstanding achievements in and/or contributions to the field of biomaterials research.

Finbloom lands first faculty position

Stupp Lab alum Joel Finbloom recently joined the faculty at the University of British Columbia as an Assistant Professor of Nanomedicine and Chemical Biology. Finbloom performed undergraduate research on dynamic materials for drug delivery applications in the Stupp group. He then completed his PhD in chemistry at the University of California, Berkeley, before a postdoctoral stint at the University of California, San Francisco.

Appelt contributes to COVID-19 vaccine development in South Africa

Liz Appelt, a former undergraduate in the Stupp laboratory, spent her summer helping a South Africa-based biotechnology company prepare its mRNA COVID-19 vaccine for animal and clinical trials — part of an initiative to increase vaccine production in low- and middle-income countries. During a three-month internship, Appelt learned the company’s laboratory techniques, helped validate its Good Manufacturing Practices facility, and worked on documentation and compliance with regulatory authorities. She is currently a fourth-year PhD candidate in Chemical and Biological Engineering at the University of Wisconsin-Madison.

Cao named Henry Dreyfus Teacher-Scholar

Former Stupp group postdoc Dennis Cao, now an Associate Professor of Chemistry at Macalester College, received a 2022 Henry Dreyfus Teacher-Scholar Award. The award honors young faculty in the chemical sciences who have created an outstanding independent body of scholarship and are deeply committed to education with undergraduates. Each winner receives an unrestricted research grant of $75,000.

Amstutz wins Inventor of the Year Award

Aaron Amstutz, a former master’s student in the Stupp laboratory, has been named Inventor of the Year by the Intellectual Property Owners Education Foundation along with Luke Haverhals. The two chemists, both with Natural Fiber Welding, were recognized for inventing materials that are naturally low carbon and completely circular. The company aims to create sustainable, plastic-free materials for a variety of products, including clothing, upholstery, footwear, and automobile interiors.

Study expands horizons for DNA nanotechnology

Arizona State University researchers including former Stupp group member Nicholas Stephanopoulos published the first systematic study of Holliday junctions, basic building blocks used in the fabrication of many DNA nanoforms. The work, published in Nature Communications, used crystallography techniques to describe the characteristics of 36 basic variants of the Holliday junction.

Researchers develop virus-killing face masks

Former Stupp laboratory member Helen Zha and colleagues successfully grafted broad-spectrum antimicrobial polymers onto the polypropylene filters used in N95 face masks, according to a study published in ACS Applied Materials and Interfaces. The antiviral and antibacterial masks may be worn for longer periods of time, which would result in less plastic waste as the masks would not need to be replaced as often.

New technique for fabricating next-generation transistors

Using hydrocarbon seeds, materials engineers at the University of Wisconsin-Madison have developed a new method for making graphene nanoribbons. In the future, the technique may allow the industrial-scale fabrication of the ribbons, enabling them to be used as next-generation transistors on computer chips and other “post-silicon” devices. The research was led by Michael Arnold, a Professor of Materials Science and Engineering at UW-Madison and a former PhD student in the Stupp laboratory.

Meet the Researchers: Tristan Clemons

Tristan Clemons was a Research Associate in the Stupp laboratory and is now an Assistant Professor in the School of Polymer Science and Engineering at the University of Southern Mississippi. In this Q&A, Clemons discusses his Rising Stars of SQI Lecture, highlights from his time in the Stupp group and how his experience as an elite athlete benefits his research career.