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Graduate Student MS, Tsinghua
University, 2002 (materials science & engineering) Cook Hall
3042 (847)
467-6430 office |
Shuming Zhang |
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2D patterning technique in tumor metastasic research Using patterning and in situ hybridization techniques, different genes (upa, thrombospondin) expression pattern were observed for contacting and non-contacting cells on a single slide, which show that the factor of physical contact played an important role in deciding this pattern. Together with work from our collaborator, the physical contact's role in tumor metastasis being de-convoluted.  Fig 1: Cancer cells cluster in Bone Cells
Cells Chip Concept and fabrication As newly synthesized biomaterials coming out everyday, people have been thinking about using some systematic ways to find out optimum parameters for these materials in their fields of applications. For example, robotic printing technology has been used to make arrayed acrylate-based polymers and stem cells responses to these materials have been tested for the best combination. However, there is not such system that is designed to systematically study gel-based cell-containing materials, especially when the gel is on microscale. We are working on a system to study stem cells’ response to specially designed bioactive polymer gel in our lab. The advantage of this system includes, cells containing gel of many different components, cytokine concentrations, cytokine release speeds, epitopes, cells etc. can be made and delivered, the gels are protected from physical challenges of the culturing environments, in situ imaging of cells in different gel environments is easy to do. As a proof of principle experiment, stem cells’ responses to cytokine binding PA system is the first field application of this idea.
Fig 2: MSC differentiation | |
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