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Graduate Student
Materials Science & Engineering

MS, Tsinghua University, 2002 (materials science & engineering)
BS, Tsinghua University, 2000 (materials science & engineering)

Cook Hall 3042
2220 Campus Drive
Evanston, IL 60208-3108

(847) 467-6430 office
(847) 467-6415 lab
(847) 491-3010 facsimile

Email Shuming

Shuming Zhang

2D patterning technique in tumor metastasic research

Using patterning and in situ hybridization techniques, different genes (upa, thrombospondin) expression pattern were observed for contacting and non-contacting cells on a single slide, which show that the factor of physical contact played an important role in deciding this pattern. Together with work from our collaborator, the physical contact's role in tumor metastasis being de-convoluted.


Fig 1: Cancer cells cluster in Bone Cells

 

Cells Chip Concept and fabrication

As newly synthesized biomaterials coming out everyday, people have been thinking about using some systematic ways to find out optimum parameters for these materials in their fields of applications. For example, robotic printing technology has been used to make arrayed acrylate-based polymers and stem cells responses to these materials have been tested for the best combination. However, there is not such system that is designed to systematically study gel-based cell-containing materials, especially when the gel is on microscale. We are working on a system to study stem cellsí response to specially designed bioactive polymer gel in our lab. The advantage of this system includes, cells containing gel of many different components, cytokine concentrations, cytokine release speeds, epitopes, cells etc. can be made and delivered, the gels are protected from physical challenges of the culturing environments, in situ imaging of cells in different gel environments is easy to do.

As a proof of principle experiment, stem cellsí responses to cytokine binding PA system is the first field application of this idea.

Fig 2: MSC differentiation
Trends in Molecular Medicine V.7 No. 6 June 2001 259

 

 

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Robert R. McCormick School of Engineering & Applied Science | Department of Materials Science & Engineering
Judd A. and Marjorie Weinberg College of Arts and Sciences | Department of Chemistry
Feinberg School of Medicine
| Institute for Bioengineering and Nanoscience in Advanced Medicine
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