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Northwestern University


'Dancing molecules' successfully repair severe spinal cord injuries

Northwestern University, News Center

by Amanda Morris
Nov 11, 2021

After single injection, paralyzed animals regained ability to walk within four weeks.

Northwestern University researchers have developed a new injectable therapy that harnesses “dancing molecules” to reverse paralysis and repair tissue after severe spinal cord injuries. In a new study, researchers administered a single injection to tissues surrounding the spinal cords of paralyzed mice. Just four weeks later, the animals regained the ability to walk. More

Aquatic robot inspired by sea creatures walks, rolls, transports cargo

Northwestern University, News Center

by Amanda Morris
Dec 29, 2020

Soft material is powered by light and rotating magnetic fields.

Northwestern University researchers have developed a first-of-its-kind life-like material that acts as a soft robot. It can walk at human speed, pick up and transport cargo to a new location, climb up hills and even break-dance to release a particle.

Nearly 90% water by weight, the centimeter-sized robot moves without complex hardware, hydraulics or electricity. Instead, it is activated by light and walks in the direction of an external rotating magnetic field. More

Northwestern Scientists Publish Guiding Principles for COVID-19 Vaccine Development

McCormick School of Engineering, News & Events
by Daniel Allar
July 21, 2020

Four takeaways from research could help scientists working to develop safe and effective vaccine.

A team from Northwestern including Northwestern Engineering’s Michael Jewett and Samuel Stupp has created guidelines to assist in developing a safe and effective vaccine for COVID-19.

Published July 21 in ACS Central Science, the principles were gleaned from early research on COVID-19 and data from the 2003 SARS outbreak, caused by SARS-CoV, a very similar virus to SARS-CoV-2, which causes COVID-19. More

Northwestern, MIT Researchers Develop Novel Materials for Energy and Sensing

McCormick School of Engineering, News & Events
by Daniel Allar
July 6, 2020

Strategically varying composition of organic layers can "tune" color of light absorbed by perovskites.

A team of researchers from Northwestern University and the Massachusetts Institute of Technology (MIT) has demonstrated the ability to fine-tune the electronic properties of hybrid perovskite materials, which have drawn enormous interest as potential next-generation optoelectronic materials for devices such as solar cells and light sources.
The materials are classified as “hybrid” because they contain inorganic components like metals as well as organic molecules with elements like carbon and nitrogen, organized into nanoscale layers. In the paper “Tunable exciton binding energy in 2D hybrid layered perovskites through donor–acceptor interactions within the organic layer,” published July 6 in the journal Nature Chemistry, the researchers showed that by strategically varying the composition of the organic layers, they could tune the color of light absorbed by the perovskite and also the wavelength at which the material emitted light. Importantly, they accomplished this without substantially changing the inorganic component. More




“Tunable Exciton Binding Energy in Two-Dimensional Hybrid Layered Perovskites Through Organic-Layer Donor–Acceptor Interactions”

Courtesy of Nature Chemistry

Nature Chemistry 12, (2020) 672-682.
Passarelli et al.

“Oriented Multiwalled Organic-Co(OH)2 Nanotubes for Energy Storage”

Courtesy of Advanced Functional Materials

Advanced Functional Materials 28(3), (2018) e1702320. 
Lau et al.

"Supramolecular Assembly of Peptide Amphiphiles"

Courtesy of Accounts of Chemical Research

Accounts of Chemical Research 50(10), (2017) 2440-2448.
Hendricks et al.

“Sulfated Glycopeptide Nanostructures for Multipotent Protein Activation”

Courtesy of Nature Nanotechnology

Nature Nanotechnology 12, (2017) 821-829.
Lee et al.

"Simultaneous Covalent and Non-Covalent Hybrid Polymerizations"

Courtesy of Science

Science 351(6272), (2016) 497-502.
Yu et al.

“Energy Landscapes and Function of Supramolecular Systems”

Courtesy of Nature Materials

Nature Materials 15(4), (2016) 469-476.
Tantakitti et al.

“Supramolecular Packing Controls H2 Photocatalysis in Chromophore Amphiphile Hydrogels”

Courtesy of JACS

J. Am. Chem. Soc. 137(48), (2015) 15241- 15246.
Weingarten et al.


Group Meetings

*Currently Via Zoom*

Bi-Weekly Wednesday at 11am

4/13/22 = Huachuan Du

4/27/2022 = Kristen Wek

5/11/2022 = Jacob Kupferberg

5/27/2022 = Eric Bruckner

6/8/2022 = Jack Kolberg-Edelbrock

Weekly Subgroup M
*currently via Zoom - please see below for contact information*

Subgroup - Biomaterials:
Fridays, 11:00a.m., SQI Conference Rm 11-247, Chicago Campus (Lurie)
Contact: Cara Smith

Combined Subgroup - Self-Assembly & Energy Materials:
Mondays, 1:00p.m., Cook 3024
Contact: Simon Egner


The Stupp Group

Stupp Group 2017





The Stupp Laboratory
Cook Hall 1127
2220 Campus Drive
Evanston, IL 60208-3108

(847) 491-3002 phone
(847) 491-3010 facsimile

Samuel I. Stupp
Board of Trustees Professor of
Materials Science, Chemistry, Medicine, & Biomedical Engineering
Director, Simpson Querrey Insitute for BioNanotechnology

Melissa Koelling
Program Coordinator
Evanston Campus

Maura Walsh email link
Executive Coordinator
Chicago Campus


* Note *
Inquiries for undergraduate research opportunities should be directed to Prof. Liam Palmer:

Recently Published
“Supramolecular Copolymers of Peptides and Lipidated Peptides and their Therapeutic Potential”Qiu, R.; Sasselli, I. R.; Álvarez, Z.; Sai, H.; Ji, W.; Palmer, L. C.; Stupp, S. I. J. Am. Chem. Soc (2022), In Press. https://doi/10.1021/jacs.2c00433

“Designing Supramolecular Polymers with Nucleation and Growth Processes” Bruckner, E. P.; Stupp, S. I. Polymer International 2022,

“Acid-Base Equilibrium and Dielectric Environment Regulate Charge in Supramolecular Nanofibers” Nap R.J., Qiao B., Palmer L.C., Stupp S.I., Olvera de la Cruz M. and Szleifer I. Frontiers in Chemistry (2022), 10:852164.

“Controlling the Shape Morphology of Origami-Inspired Photoresponsive Hydrogels”Aggarwal, A.; Li, C.; Stupp, S. I.; Olvera de la Cruz, M. Soft Matter (2022), 18, 2193-2201

“Photocatalytic Aqueous CO2 Reduction to CO and CH4 Sensitized by Ullazine Supramolecular Polymers”
Dumele, O.; Dordevic, L.; Sai, H.; Cotey, T. J.; Sangji, M. H.; Sato, K.; Dannenhoffer, A. J.; Stupp, S. I. J. Am. Chem. Soc (2022), 144 (7), 3127-3136

“Modelling Interactions Within and Between Peptide Amphiphile Supramolecular Filaments”
Sasselli, I. R.; Syrgiannis, Z.; Sather, N.; Palmer, L. C; Stupp. S. I. J. Phys. Chem. B 126(3), (2022) 650-659.

“Crystalline Supramolecular Polymers: Dynamics, Chirality, and Function”
Stupp, S. I.; Palmer, L. C.; Sai, H. Israel Journal of Chemistry 61(11-12), (2021) 873-883.

Molecular Insight into the β-Sheet Twist and Related Morphology of Self-Assembled Peptide Amphiphile Ribbons
Xiong, Q; Stupp, S. I.; Schatz, G. C. J. Phys. Chem. Lett. 12(46), (2021) 11238–11244.

“Bioactive Scaffolds With Enhanced Supramolecular Motion Promote Recovery from Spinal Cord Injury”
Álvarez, Z.; Edelbrock, A. N.; Sasselli, I. R.; Ortega, J. A.; Syrgiannis, Z.; Mirau, P. A.; Chen, F.; Qiu, R.; Chin, S.M.; Weigand, S.; Kiskinis, E.; Stupp, S. I. Science 374(6569), (2021) 848-856.




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Northwestern University
Robert R. McCormick School of Engineering & Applied Science | Department of Materials Science & Engineering
Judd A. and Marjorie Weinberg College of Arts and Sciences | Department of Chemistry
Feinberg School of Medicine | Simpson Querrey Institute for BioNanotechnology
The Stupp Laboratory | Cook Hall 1127 | 2220 Campus Drive | Evanston, IL 60208 | U.S.A.
Phone: 847-491-3002 Fax: 847-491-3010
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