New Bio-inspired Dynamic Materials Transform Themselves

McCormick School of Engineering, News & Events
by Emily Ayshford
Oct 4, 2018

Highly dynamic synthetic superstructures self-assemble, change stiffness of soft materials. then revert, while providing new clues on brain, spinal cord injuries and neurological disease
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New technology to manipulate cells could one day help treat Parkinson's, arthritis, other diseases

Northwestern University, News Center
by Kristin Samuelson
July 10, 2017

DNA strands in materials act like traffic signals to start, stop cell activity or regenerate tissue

EVANSTON, Ill. --  A groundbreaking advancement in materials from Northwestern University could potentially help patients requiring stem cell therapies for spinal cord injuries, stroke, Parkinson’s disease, Alzheimer’s disease, arthritic joints or any other condition requiring tissue regeneration, according to a new study.
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Sugar-coated nanomaterial excels at promoting bone growth

Northwestern University, News Center
by Megan Fellman
June 19, 2017

Method offers pathway for improving patient outcomes after spinal fusion surgery

EVANSTON - There hasn’t been a gold standard for how orthopaedic spine surgeons promote new bone growth in patients, but now Northwestern University scientists have designed a bioactive nanomaterial that is so good at stimulating bone regeneration it could become the method surgeons prefer.
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Samuel Stupp honored with Royal Society of Chemistry’s Soft Matter and Biophysical Chemistry Award

Northwestern University, News Center
by Megan Fellman
May 9, 2016

EVANSTON, Ill. -- Samuel I. Stupp, the director of the Simpson Querrey Institute for BioNanotechnology at Northwestern University, has received the Soft Matter and Biophysical Chemistry Award from the Royal Society of Chemistry -- the largest organization in Europe dedicated to advancing the chemical sciences. The award is given by the Faraday Division of the Royal Society, which provides a forum for physical and biophysical chemistry, molecular and chemical physics, and theoretical chemistry.
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Researchers Develop Completely New Kind of Polymer

Northwestern University, News Center
by Megan Fellman
January 28, 2016

Hybrid polymers could lead to new concepts in self-repairing materials, drug delivery and artificial muscles

EVANSTON, Ill. --- Imagine a polymer with removable parts that can deliver something to the environment and then be chemically regenerated to function again. Or a polymer that can lift weights, contracting and expanding the way muscles do......more

Hybrid Polymer Blends Covalent And Supramolecular Components

Chemical & Engineering News
by Bethany Halford
February 1, 2016

Polymers: Supramolecular component can be removed and reconstituted on demand to yield soft materials with novel delivery or repair functions

By combining monomers that form a covalently linked polymer with a monomer that assembles noncovalently into a supramolecular polymer, researchers have created a novel soft material that’s distinct from the forms these monomers take on their own. The new hybrid structure, created by Samuel I. Stupp and colleagues at Northwestern University, can be partially disassembled and reassembled on demand, creating a material that could have applications in drug delivery and self-healing materials......more

“Oriented Multiwalled Organic-Co(OH)2 Nanotubes for Energy Storage”



Advanced Functional Materials 28(3), (2018) e1702320. 
Lau et al.

"Supramolecular Assembly of Peptide Amphiphiles"

Accounts of Chemical Research 50(10), (2017) 2440-2448.
Hendricks et al.

“Sulfated Glycopeptide Nanostructures for Multipotent Protein Activation”

Nature Nanotechnology 12, (2017) 821-829.
Lee et al.

"Simultaneous Covalent and Non-Covalent Hybrid Polymerizations"

Science 351(6272), (2016) 497-502.
Yu et al.

“Energy Landscapes and Function of Supramolecular Systems”

Nature Materials 15(4), (2016) 469-476.
Tantakitti et al.

“Supramolecular Packing Controls H2 Photocatalysis in Chromophore Amphiphile Hydrogels”
ACS EDITORS’ CHOICE ARTICLE 

J. Am. Chem. Soc. 137(48), (2015) 15241- 15246.
Weingarten et al.

“Bioactive DNA-Peptide Nanotubes Enhance the Differentiation of Neural Stem Cells Into Neurons”

Nano Letters 15(1), (2015) 603-609.
Stephanopoulos et al

“Internal Dynamics of a Supramolecular Nanofiber”

Nature Materials 13, (2014) 812-816.
Ortony et al.

“Room-Temperature Ferroelectricity in Supramolecular Networks of Charge-Transfer Complexes”

Nature 488(7412), (2012) 485-489.
Tayi et al.

Group Meetings

Tues 12/18/18 @ 2pm in Searle
Allie Edelbrock and Adam Dannenhoffer

* Winter 2019 Schedule TBD *

Weekly Subgroup Meetings

Subgroup - Biomaterials:
Thursdays, 9:30 a.m., SQI Conference Rm 11-247, Chicago campus (Lurie) 11th Fl
Contact: Alexandra Edelbrock
AlexandraKolberg2014@u.northwestern.edu

Combined Subgroup - Self-Assembly & Energy Materials:
Tuesdays, 11:00 a.m., Cook 3024
Contact: Eric Bruckner
ericbruckner2016@u.northwestern.edu
or
Contact: James Passarelli
JamesPassarelli2015@u.northwestern.edu

The Stupp Group 2018

The Stupp Laboratory
Cook Hall 1127
2220 Campus Drive
Evanston, IL 60208-3108

(847) 491-3002 phone
(847) 491-3010 facsimile

Samuel I. Stupp
Board of Trustees Professor of
Materials Science, Chemistry, Medicine, & Biomedical Engineering
Director, Simpson Querrey Insitute for BioNanotechnology

Laura Fields
Program Coordinator
Evanston Campus

Maura Walsh
Administrative Coordinator
Chicago Campus

* Note *
Inquiries for undergraduate research opportunities should be directed to Prof. Liam Palmer: liam-palmer@northwestern.edu

"Peptide-siRNA Supramolecular Particles for Neural Cell Transfection"
Hernandez-Garcia A.; Álvarez Z.; Simkin D.; Madhan A.; Pariset E.; Tantakitti F.; de J.Vargas-Dorantes, O.; Lee S. S.; Kiskinis E.; Stupp S. I. Advanced Science (2018), in press DOI: 10.1002/advs.201801458

"Bioactive Nanofibers Induce Neural Transdifferentiation of Human Bone Marrow Mesenchymal Stem Cells"
Ji, W.; Álvarez, Z.; Edelbrock, A. N.; Sato, K.; Stupp, S. I. ACS Applied Materials & Interfaces 10(48), (2018) 41046-41055.

"Sonic Hedgehog Regulation of Cavernous Nerve Regeneration and Neurite Formation in Aged Pelvic Plexus"
Dobbs, R.; Kalmanek, E.; Choe, S.; Harrington, D. A.; Stupp, S. I.; McVary, K. T.; Podlasek, C. A. Experimental Neurology 312, (2019) 10-19.   

"Pelvic and Hypogastric Nerves are Injured in a Rat Prostatectomy Model, Contributing to Development of Stress Urinary Incontinence"
Hehemann, M.; Choe, S.; Kalmanek, E.; Harrington, D. A.; Stupp, S. I.; McVary, K. T.; Podlasek, C. A. Scientific Reports 8:16432 (2018)

"Self-Repair of Structure and Bioactivity in a Supramolecular Nanostructure"
Chen, C. H.; Palmer, L. C.; Stupp, S. I. Nano Letters 18(11), (2018) 6832-6841.

"Reversible Self-Assembly of Superstructured Networks"
Freeman, R.; Han, M.; Álvarez, Z.; Lewis, J. A.; Wester, J. R.; Stephanopoulos, N.; McClendon, M. T.; Lynsky, C.; Godbe, J. M.; Sangji, H.; Luijten E.; Stupp, S. I.
Science 362(6416), (2018) 808-813.

"Anisotropic Contraction of Fiber-Reinforced Hydrogels"
Liu, S.; Stupp, S. I.; Olvera de la Cruz, M. Soft Matter(2018) 14, 7731-7739.

"Supramolecular Nanostructure Activates TrkB Receptor Signaling of Neuronal Cells by Mimicking Brain-Derived Neurotropic Factor"
Edelbrock, A. N.; Álvarez, Z.; Simkin, D.; Fyrner, T.; Chin, S. M.; Sato, K.; Kiskinis, E.; Stupp, S. I. Nano Letters 18(10), (2018) 6237-6247.

"Sonic Hedgehog Regulation of Human Rhabdosphincter Muscle: Potential Implications for Treatment of Stress Urinary Incontinence"
Hehemann, M.; Kalmanek, E.; Choe, S.; Dynda, D.; Hu, W-Y.; Quek, M. L.; Harrington, D. A.; Stupp, S. I.; McVary, K. T.; Podlasek, C. A. Neurourology and Urodynamics 37(8), (2018) 2551-2559.