New technology to manipulate cells could one day help treat Parkinson's, arthritis, other diseases

Northwestern University, News Center
by Kristin Samuelson
July 10, 2017

DNA strands in materials act like traffic signals to start, stop cell activity or regenerate tissue

EVANSTON, Ill. --  A groundbreaking advancement in materials from Northwestern University could potentially help patients requiring stem cell therapies for spinal cord injuries, stroke, Parkinson’s disease, Alzheimer’s disease, arthritic joints or any other condition requiring tissue regeneration, according to a new study.
More  

Sugar-coated nanomaterial excels at promoting bone growth

Northwestern University, News Center
by Megan Fellman
June 19, 2017

Method offers pathway for improving patient outcomes after spinal fusion surgery

EVANSTON - There hasn’t been a gold standard for how orthopaedic spine surgeons promote new bone growth in patients, but now Northwestern University scientists have designed a bioactive nanomaterial that is so good at stimulating bone regeneration it could become the method surgeons prefer.
More  

Samuel Stupp honored with Royal Society of Chemistry’s Soft Matter and Biophysical Chemistry Award

Northwestern University, News Center
by Megan Fellman
May 9, 2016

EVANSTON, Ill. -- Samuel I. Stupp, the director of the Simpson Querrey Institute for BioNanotechnology at Northwestern University, has received the Soft Matter and Biophysical Chemistry Award from the Royal Society of Chemistry -- the largest organization in Europe dedicated to advancing the chemical sciences. The award is given by the Faraday Division of the Royal Society, which provides a forum for physical and biophysical chemistry, molecular and chemical physics, and theoretical chemistry.
More

Researchers Develop Completely New Kind of Polymer

Northwestern University, News Center
by Megan Fellman
January 28, 2016

Hybrid polymers could lead to new concepts in self-repairing materials, drug delivery and artificial muscles

EVANSTON, Ill. --- Imagine a polymer with removable parts that can deliver something to the environment and then be chemically regenerated to function again. Or a polymer that can lift weights, contracting and expanding the way muscles do......more

Hybrid Polymer Blends Covalent And Supramolecular Components

Chemical & Engineering News
by Bethany Halford
February 1, 2016

Polymers: Supramolecular component can be removed and reconstituted on demand to yield soft materials with novel delivery or repair functions

By combining monomers that form a covalently linked polymer with a monomer that assembles noncovalently into a supramolecular polymer, researchers have created a novel soft material that’s distinct from the forms these monomers take on their own. The new hybrid structure, created by Samuel I. Stupp and colleagues at Northwestern University, can be partially disassembled and reassembled on demand, creating a material that could have applications in drug delivery and self-healing materials......more

“Sulfated Glycopeptide Nanostructures for Multipotent Protein Activation”

Nature Nanotechnology 12, (2017) 821-829.
Lee et al.

"Simultaneous Covalent and Non-Covalent Hybrid Polymerizations"

Science 351(6272), (2016) 497-502.
Yu et al.

“Energy Landscapes and Function of Supramolecular Systems”

Nature Materials 15(4), (2016) 469-476.
Tantakitti et al.

“Supramolecular Packing Controls H2 Photocatalysis in Chromophore Amphiphile Hydrogels”
ACS EDITORS’ CHOICE ARTICLE 

J. Am. Chem. Soc. 137(48), (2015) 15241- 15246.
Weingarten et al.

“Bioactive DNA-Peptide Nanotubes Enhance the Differentiation of Neural Stem Cells Into Neurons”

Nano Letters 15(1), (2015) 603-609.
Stephanopoulos et al

“Internal Dynamics of a Supramolecular Nanofiber”

Nature Materials 13, (2014) 812-816.
Ortony et al.

“Room-Temperature Ferroelectricity in Supramolecular Networks of Charge-Transfer Complexes”

Nature 488(7412), (2012) 485-489.
Tayi et al.

Group Meetings

10/3/17 Tuesday @ 6:00pm - JWing Atrium - Open House

* Fall Group Meeting Schedule is TBD *

Weekly Subgroup Meetings

Subgroup 1 - Energy Materials:
Tuesdays, 2:00 p.m., Cook 3024
Contact: Nick Sather
NicholasSather2013@u.northwestern.edu

Subgroup 2 - Self-Assembly:
Fridays, 11:00 a.m., Cook 3024
Contact: Mark Hendricks
mark.hendricks@northwestern.edu

Subgroup 3 - Biomaterials:
Mondays, 2:00 p.m., SQI Conference Rm 11-247, Chicago campus (Lurie) 11th Fl
Contact: Alexandra Edelbrock
AlexandraKolberg2014@u.northwestern.edu

The Stupp Group 2017

The Stupp Laboratory
Cook Hall 1127
2220 Campus Drive
Evanston, IL 60208-3108

(847) 491-3002 phone
(847) 491-3010 facsimile

Samuel I. Stupp
Board of Trustees Professor of
Materials Science, Chemistry, Medicine, & Biomedical Engineering
Director, Simpson Querrey Insitute for BioNanotechnology

Laura Fields
Program Coordinator
Evanston Campus

Maura Walsh
Administrative Coordinator
Chicago Campus

* Note *
Inquiries for undergraduate research opportunities should be directed to Prof. Liam Palmer: liam-palmer@northwestern.edu

“Injectable Biomimetic Liquid Crystalline Scaffolds Enhance Muscle Stem Cell Transplantation”
Sleep, E.; Cosgrove, B. D.; McClendon, M. T.; Preslar, A. T.; Chen, C. H.; Sangji, M. H.; Rubert Pérez, C. M.; Haynes, R. D.; Meade, T. J.; Blau, H. M.; Stupp, S. I. Proc. Natl. Acad. Sci. (2017) in press DOI:10.1073/pnas.1708142114

"Supramolecular Assembly of Peptide Amphiphiles"
Hendricks, M. P.; Sato, K.; Palmer, L. C.; Stupp, S. I.
Accounts of Chemical Research (2017) in press DOI: 10.1021/acs.accounts.7b00297

"Mimicking the Bioactivity of Fibroblast Growth Factor-2 using Supramolecular Nanoribbons"
Rubert Pérez, C. M.; Álvarez, Z.; Chen, F.; Aytun, T.; Stupp, S. I. ACS Biomater. Sci. Eng. (2017) in press DOI:10.1021/acsbiomaterials.7b00347 ACS EDITORS’ CHOICE ARTICLE

“Instructing Cells with Programmable Peptide-DNA Hybrids”
Freeman, R.; Stephanopoulos, N.; Alvarez, Z.; Lewis, J. A.; Sur, S.; Serrano, C. M.; Boekhoven, J.; Lee, S. S.; Stupp, S. I. Nature Communications 8:15982, (2017) doi:10.1038/ncomms15982

“Ferroelectric Polarization and Second Harmonic Generation in Supramolecular Co-Crystals with Two Axes of Charge-Transfer”
Narayanan, A.; Cao, D.; Frazer, L.; Tayi, A. S.; Blackburn, A. K.; Sue, A. C-H.; Ketterson, J. B.; Stoddart, J. F.; Stupp, S. I. J. Am. Chem. Soc. 139(27), (2017) 9186-9191.

"Programmable Assembly of Peptide Amphiphile Via Non-Covalent to Covalent Bond Conversion"
Sato, K.; Ji, W.; Palmer, L. C.; Weber, B.; Barz, M.; Stupp, S. I. J. Am. Chem. Soc. 139(26), (2017) 8995-9000.

"Water Dynamics from the Surface to the Interior of a Supramolecular Nanostructure"
Ortony, J. H.; Qiao, B.; Newcomb, C. J.; Keller, T. J.; Palmer, L. C.; Deiss-Yehiely, E.; Olvera de la Cruz, M.; Han, S.; Stupp, S. I. J. Am. Chem. Soc. 139(26), (2017) 8915-8921.

“Sulfated Glycopeptide Nanostructures for Multipotent Protein Activation”
Lee. S. S.; Fyrner, T.; Chen, F.; Alvarez, Z.; Sleep, E.; Chun, D. S.; Weiner, J. A.; Cook, R. W.; Freshman, R. D.; Schallmo, M. S.; Katchko, K. M.; Schneider, A. D.; Smith, J. T.; Yun, C.; Singh, G.; Hashmi, S. Z.; McClendon, M. T.; Yu, Z.; Stock, S. R.; Hsu, W. K.; Hsu, E. L.; Stupp, S. I. Nature Nanotechnology 12, (2017) 821-829.